Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects
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منابع مشابه
Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects
Interaction between the ureteric-bud epithelium and the metanephric mesenchyme is important for kidney development. Six1 and Six4 are the mammalian homologs of Drosophila sine oculis, and they are coexpressed in the nephrogenic mesenchyme. Six1-deficient mice show varying kidney defects, while Six4-deficient mice have no apparent abnormalities. Here, we report Six1/Six4-deficient mice that we g...
متن کاملSix1 is required for the early organogenesis of mammalian kidney.
The murine Six gene family, homologous to Drosophila sine oculis (so) which encodes a homeodomain transcription factor, is composed of six members (Six1-6). Among the six members, only the Six2 gene has been previously shown to be expressed early in kidney development, but its function is unknown. We have recently found that the Six1 gene is also expressed in the kidney. In the developing kidne...
متن کاملSix1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo.
In mammals, Six5, Six4 and Six1 genes are co-expressed during mouse myogenesis. Six4 and Six5 single knockout (KO) mice have no developmental defects, while Six1 KO mice die at birth and show multiple organ developmental defects. We have generated Six1Six4 double KO mice and show an aggravation of the phenotype previously reported for the single Six1 KO. Six1Six4 double KO mice are characterize...
متن کاملDefects of urogenital development in mice lacking Emx2.
The homeobox gene Emx2 is a mouse homologue of a Drosophila head gap gene empty spiracles (ems) and is essential for the development of dorsal telencephalon (Yoshida, M., Suda, Y., Matsuo, I., Miyamoto, N., Takeda, N., Kuratani, S. and Aizawa, S. (1997) Development 124, 101-111). At the same time, Emx2 is expressed in the epithelial components of the developing urogenital system and, in Emx2 mu...
متن کاملTargeted mutation of Wt1 in mice results in bilateral renal agenesis, characterized by apoptosis of the metanephric mesenchyme and failure of ureteric bud invasion into the metanephric mesenchyme
INTRODUCTION The pediatric kidney malignancy Wilms’ tumor has an incidence of 1 in 10 000 in North America (Matsunaga, 1981), making it the most common solid tumor in childhood (Bennington and Beckwith, 1975). Wilms’ tumor is thought to arise from a single transformed pluripotent nephron progenitor cell whose progeny fail to undergo normal differentiation. WT1 was the first gene identified as m...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2007
ISSN: 0925-4773
DOI: 10.1016/j.mod.2007.01.002